THE NATURE OF PROBLEM BACTERIA: IS RESISTANCE ENOUGH? Staphylococcal Small Colony Variants Have Novel Mechanisms for Antibiotic Resistance
نویسندگان
چکیده
Richard A. Proctor, Barbara Kahl, Christof von Eiff, From the Institute of Medical Microbiology, University of Muenster, Germany; and the Division of Infectious Diseases, Department of Pierre E. Vaudaux, Daniel P. Lew, and Georg Peters Medicine, Geneva University Hospital, Geneva, Switzerland; and the Departments of Medicine and Medical Microbiology/Immunology, University of Wisconsin, Madison, Wisconsin, USA
منابع مشابه
Alternative Evolutionary Pathways for Drug-Resistant Small Colony Variant Mutants in Staphylococcus aureus
Staphylococcus aureus is known to generate small colony variants (SCVs) that are resistant to aminoglycoside antibiotics and can cause persistent and recurrent infections. The SCV phenotype is unstable, and compensatory mutations lead to restored growth, usually with loss of resistance. However, the evolution of improved growth, by mechanisms that avoid loss of antibiotic resistance, is very po...
متن کاملNew update on molecular determinants of colistin resistance in bacteria
Colistin relates to the polymyxin group of antibiotics. This antibiotic is still used to destroy gram-negative bacteria as a last resort. However, resistance to this antibiotic has been reported and is appearing day by day. Not much information is available on the exact mechanisms of resistance to this antibiotic. Also, not enough information about pharmacokinetics and pharmacodynamics is avail...
متن کاملStaphylococcal small colony variants have novel mechanisms for antibiotic resistance.
Over the past 4 years, a variant subpopulation of Staphylococcus aureus has been characterized that is defective in electron transport. These organisms grow slowly and are typical of the previously described small colony variants (SCVs). Indeed, many earlier papers included data that are consistent with defective respiratory activity in SCVs. We present a hypothesis that serves as biochemical b...
متن کاملStudy of Organic Solvent Tolerance and Increased Antibiotic Resistance Properties in E. coli gyrA Mutants
Ciprofloxacin is one of the most widely used antibiotics for the treatment of several infections caused by Gram-negative bacteria, like E. coli. Changes in gyrA, encoding GyrA subunit of DNA gyrase, cause the resistance to ciprofloxacin. Some ciprofloxacin resistant gyrA mutants acquired constitutive expression of marRAB operon due to the gaining mutations in marR, a repressor of this operon...
متن کاملStudy of Organic Solvent Tolerance and Increased Antibiotic Resistance Properties in E. coli gyrA Mutants
Ciprofloxacin is one of the most widely used antibiotics for the treatment of several infections caused by Gram-negative bacteria, like E. coli. Changes in gyrA, encoding GyrA subunit of DNA gyrase, cause the resistance to ciprofloxacin. Some ciprofloxacin resistant gyrA mutants acquired constitutive expression of marRAB operon due to the gaining mutations in marR, a repressor of this operon...
متن کامل